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vLLM Deployment on the RTX 5090 32 GB: The Production Config

The vLLM launch flags that exploit Blackwell properly on a 5090 — FP8 weights, FP8 KV cache, prefix caching, optional speculative decoding.

The 5090's Blackwell silicon needs the right vLLM flags to actually deliver its 2× FP8 throughput. Defaults leave money on the table.

TL;DR

5090 vLLM config: FP8 weights, FP8 KV cache, max-num-seqs=128, max-model-len=32768, prefix caching, optional speculative decoding. ~1,920 tok/s on Mistral 7B FP8.

Install

pip install vllm==0.6.3
# 5090 needs NVIDIA driver 555+ (Blackwell)

Optimal config

vllm serve mistralai/Mistral-7B-Instruct-v0.3 \
  --quantization fp8 \
  --kv-cache-dtype fp8_e4m3 \
  --max-model-len 32768 \
  --max-num-seqs 128 \
  --gpu-memory-utilization 0.92 \
  --enable-prefix-caching

Speculative decoding option

# Add for ~1.5× speedup on chat workloads
--speculative-model meta-llama/Llama-3.2-1B-Instruct \
--num-speculative-tokens 5

Verdict

The 5090 is the best per-pound flagship for AI inference in 2026. This config gets you ~3× the throughput of naive defaults.

Bottom line

5090 + FP8 + spec decoding = best production config. See 5090 spec breakdown.

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